Paclitaxel-Trastuzumab Mixed Nanovehicle to Target HER2-Overexpressing Tumors
Identifieur interne : 000553 ( Main/Exploration ); précédent : 000552; suivant : 000554Paclitaxel-Trastuzumab Mixed Nanovehicle to Target HER2-Overexpressing Tumors
Auteurs : Celia Nieto [Espagne] ; Ariana Centa [Espagne] ; Jesús A. Rodríguez-Rodríguez [Espagne] ; Atanasio Pandiella [Espagne] ; Eva M. Martín Del Valle [Espagne]Source :
- Nanomaterials [ 2079-4991 ] ; 2019.
Abstract
Paclitaxel is one of the most widely used chemotherapeutic agents thanks to its effectiveness and broad spectrum of antitumor activity. However, it has a very poor aqueous solubility and a limited specificity. To solve these handicaps, a novel paclitaxel-trastuzumab targeted transport nanosystem has been developed and characterized in this work to specifically treat cancer cells that overexpress the human epidermal growth factor receptor-2 (HER2). Methods: Alginate and piperazine nanoparticles were synthetized and conjugated with paclitaxel:β-cyclodextrins complexes and trastuzumab. Conjugated nanoparticles (300 nm) were characterized and their internalization in HER2-overexpressing tumor cells was analyzed by immunofluorescence. Its specific antitumor activity was studied
Url:
DOI: 10.3390/nano9070948
PubMed: 31261957
PubMed Central: 6669497
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000728
- to stream Pmc, to step Curation: 000728
- to stream Pmc, to step Checkpoint: 000505
- to stream Ncbi, to step Merge: 000746
- to stream Ncbi, to step Curation: 000746
- to stream Ncbi, to step Checkpoint: 000746
- to stream Main, to step Merge: 000553
- to stream Main, to step Curation: 000553
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Paclitaxel-Trastuzumab Mixed Nanovehicle to Target HER2-Overexpressing Tumors</title><author><name sortKey="Nieto, Celia" sort="Nieto, Celia" uniqKey="Nieto C" first="Celia" last="Nieto">Celia Nieto</name><affiliation wicri:level="2"><nlm:aff id="af1-nanomaterials-09-00948">Departamento de Ingeniería Química y Textil, Facultad de Ciencias Químicas, Universidad de Salamanca, 37008 Salamanca, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Ingeniería Química y Textil, Facultad de Ciencias Químicas, Universidad de Salamanca, 37008 Salamanca</wicri:regionArea><placeName><region nuts="2" type="communauté">Castille-et-León</region></placeName></affiliation></author><author><name sortKey="Centa, Ariana" sort="Centa, Ariana" uniqKey="Centa A" first="Ariana" last="Centa">Ariana Centa</name><affiliation wicri:level="2"><nlm:aff id="af2-nanomaterials-09-00948">Instituto de Biología Molecular y Celular del Cáncer (IBMCC), CSIC, CIBERONC-IBSAL, 37007 Salamanca, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto de Biología Molecular y Celular del Cáncer (IBMCC), CSIC, CIBERONC-IBSAL, 37007 Salamanca</wicri:regionArea><placeName><region nuts="2" type="communauté">Castille-et-León</region></placeName></affiliation></author><author><name sortKey="Rodriguez Rodriguez, Jesus A" sort="Rodriguez Rodriguez, Jesus A" uniqKey="Rodriguez Rodriguez J" first="Jesús A." last="Rodríguez-Rodríguez">Jesús A. Rodríguez-Rodríguez</name><affiliation wicri:level="2"><nlm:aff id="af1-nanomaterials-09-00948">Departamento de Ingeniería Química y Textil, Facultad de Ciencias Químicas, Universidad de Salamanca, 37008 Salamanca, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Ingeniería Química y Textil, Facultad de Ciencias Químicas, Universidad de Salamanca, 37008 Salamanca</wicri:regionArea><placeName><region nuts="2" type="communauté">Castille-et-León</region></placeName></affiliation></author><author><name sortKey="Pandiella, Atanasio" sort="Pandiella, Atanasio" uniqKey="Pandiella A" first="Atanasio" last="Pandiella">Atanasio Pandiella</name><affiliation wicri:level="2"><nlm:aff id="af2-nanomaterials-09-00948">Instituto de Biología Molecular y Celular del Cáncer (IBMCC), CSIC, CIBERONC-IBSAL, 37007 Salamanca, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto de Biología Molecular y Celular del Cáncer (IBMCC), CSIC, CIBERONC-IBSAL, 37007 Salamanca</wicri:regionArea><placeName><region nuts="2" type="communauté">Castille-et-León</region></placeName></affiliation></author><author><name sortKey="Martin Del Valle, Eva M" sort="Martin Del Valle, Eva M" uniqKey="Martin Del Valle E" first="Eva M." last="Martín Del Valle">Eva M. Martín Del Valle</name><affiliation wicri:level="2"><nlm:aff id="af1-nanomaterials-09-00948">Departamento de Ingeniería Química y Textil, Facultad de Ciencias Químicas, Universidad de Salamanca, 37008 Salamanca, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Ingeniería Química y Textil, Facultad de Ciencias Químicas, Universidad de Salamanca, 37008 Salamanca</wicri:regionArea><placeName><region nuts="2" type="communauté">Castille-et-León</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31261957</idno><idno type="pmc">6669497</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669497</idno><idno type="RBID">PMC:6669497</idno><idno type="doi">10.3390/nano9070948</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000728</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000728</idno><idno type="wicri:Area/Pmc/Curation">000728</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000728</idno><idno type="wicri:Area/Pmc/Checkpoint">000505</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000505</idno><idno type="wicri:Area/Ncbi/Merge">000746</idno><idno type="wicri:Area/Ncbi/Curation">000746</idno><idno type="wicri:Area/Ncbi/Checkpoint">000746</idno><idno type="wicri:Area/Main/Merge">000553</idno><idno type="wicri:Area/Main/Curation">000553</idno><idno type="wicri:Area/Main/Exploration">000553</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Paclitaxel-Trastuzumab Mixed Nanovehicle to Target HER2-Overexpressing Tumors</title><author><name sortKey="Nieto, Celia" sort="Nieto, Celia" uniqKey="Nieto C" first="Celia" last="Nieto">Celia Nieto</name><affiliation wicri:level="2"><nlm:aff id="af1-nanomaterials-09-00948">Departamento de Ingeniería Química y Textil, Facultad de Ciencias Químicas, Universidad de Salamanca, 37008 Salamanca, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Ingeniería Química y Textil, Facultad de Ciencias Químicas, Universidad de Salamanca, 37008 Salamanca</wicri:regionArea><placeName><region nuts="2" type="communauté">Castille-et-León</region></placeName></affiliation></author><author><name sortKey="Centa, Ariana" sort="Centa, Ariana" uniqKey="Centa A" first="Ariana" last="Centa">Ariana Centa</name><affiliation wicri:level="2"><nlm:aff id="af2-nanomaterials-09-00948">Instituto de Biología Molecular y Celular del Cáncer (IBMCC), CSIC, CIBERONC-IBSAL, 37007 Salamanca, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto de Biología Molecular y Celular del Cáncer (IBMCC), CSIC, CIBERONC-IBSAL, 37007 Salamanca</wicri:regionArea><placeName><region nuts="2" type="communauté">Castille-et-León</region></placeName></affiliation></author><author><name sortKey="Rodriguez Rodriguez, Jesus A" sort="Rodriguez Rodriguez, Jesus A" uniqKey="Rodriguez Rodriguez J" first="Jesús A." last="Rodríguez-Rodríguez">Jesús A. Rodríguez-Rodríguez</name><affiliation wicri:level="2"><nlm:aff id="af1-nanomaterials-09-00948">Departamento de Ingeniería Química y Textil, Facultad de Ciencias Químicas, Universidad de Salamanca, 37008 Salamanca, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Ingeniería Química y Textil, Facultad de Ciencias Químicas, Universidad de Salamanca, 37008 Salamanca</wicri:regionArea><placeName><region nuts="2" type="communauté">Castille-et-León</region></placeName></affiliation></author><author><name sortKey="Pandiella, Atanasio" sort="Pandiella, Atanasio" uniqKey="Pandiella A" first="Atanasio" last="Pandiella">Atanasio Pandiella</name><affiliation wicri:level="2"><nlm:aff id="af2-nanomaterials-09-00948">Instituto de Biología Molecular y Celular del Cáncer (IBMCC), CSIC, CIBERONC-IBSAL, 37007 Salamanca, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto de Biología Molecular y Celular del Cáncer (IBMCC), CSIC, CIBERONC-IBSAL, 37007 Salamanca</wicri:regionArea><placeName><region nuts="2" type="communauté">Castille-et-León</region></placeName></affiliation></author><author><name sortKey="Martin Del Valle, Eva M" sort="Martin Del Valle, Eva M" uniqKey="Martin Del Valle E" first="Eva M." last="Martín Del Valle">Eva M. Martín Del Valle</name><affiliation wicri:level="2"><nlm:aff id="af1-nanomaterials-09-00948">Departamento de Ingeniería Química y Textil, Facultad de Ciencias Químicas, Universidad de Salamanca, 37008 Salamanca, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Ingeniería Química y Textil, Facultad de Ciencias Químicas, Universidad de Salamanca, 37008 Salamanca</wicri:regionArea><placeName><region nuts="2" type="communauté">Castille-et-León</region></placeName></affiliation></author></analytic><series><title level="j">Nanomaterials</title><idno type="eISSN">2079-4991</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Paclitaxel is one of the most widely used chemotherapeutic agents thanks to its effectiveness and broad spectrum of antitumor activity. However, it has a very poor aqueous solubility and a limited specificity. To solve these handicaps, a novel paclitaxel-trastuzumab targeted transport nanosystem has been developed and characterized in this work to specifically treat cancer cells that overexpress the human epidermal growth factor receptor-2 (HER2). Methods: Alginate and piperazine nanoparticles were synthetized and conjugated with paclitaxel:β-cyclodextrins complexes and trastuzumab. Conjugated nanoparticles (300 nm) were characterized and their internalization in HER2-overexpressing tumor cells was analyzed by immunofluorescence. Its specific antitumor activity was studied <italic>in vitro</italic> using human cell lines with different levels of HER2-expression. Results: In comparison with free paclitaxel:β-cyclodextrins complexes, the developed conjugated nanovehicle presented specificity for the treatment of HER2-overpressing cells, in which it was internalized by endocytosis. Conclusions: It seems that potentially avoiding the conventional adverse effects of paclitaxel treatment could be possible with the use of the proposed mixed nanovehicle, which improves its bioavailability and targets HER2-positive cancer cells.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Luzzati, T" uniqKey="Luzzati T">T. Luzzati</name></author><author><name sortKey="Parenti, A" uniqKey="Parenti A">A. Parenti</name></author><author><name sortKey="Rughi, T" uniqKey="Rughi T">T. Rughi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dickens, E" uniqKey="Dickens E">E. Dickens</name></author><author><name sortKey="Ahmed, S" uniqKey="Ahmed S">S. Ahmed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krukiewicz, K" uniqKey="Krukiewicz K">K. Krukiewicz</name></author><author><name sortKey="Zak, J K" uniqKey="Zak J">J.K. Zak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abandansari, H S" uniqKey="Abandansari H">H.S. Abandansari</name></author><author><name sortKey="Abuali, M" uniqKey="Abuali M">M. Abuali</name></author><author><name sortKey="Nabid, M R" uniqKey="Nabid M">M.R. Nabid</name></author><author><name sortKey="Niknejad, H" uniqKey="Niknejad H">H. Niknejad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, F" uniqKey="Wang F">F. Wang</name></author><author><name sortKey="Porter, M" uniqKey="Porter M">M. Porter</name></author><author><name sortKey="Konstantopoulos, A" uniqKey="Konstantopoulos A">A. Konstantopoulos</name></author><author><name sortKey="Zhang, P" uniqKey="Zhang P">P. Zhang</name></author><author><name sortKey="Cui, H" uniqKey="Cui H">H. Cui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bernabeu, E" uniqKey="Bernabeu E">E. Bernabeu</name></author><author><name sortKey="Cagel, M" uniqKey="Cagel M">M. Cagel</name></author><author><name sortKey="Lagomarsino, E" uniqKey="Lagomarsino E">E. Lagomarsino</name></author><author><name sortKey="Moretton, M" uniqKey="Moretton M">M. Moretton</name></author><author><name sortKey="Chiappetta, D A" uniqKey="Chiappetta D">D.A. Chiappetta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sofias, A M" uniqKey="Sofias A">A.M. Sofias</name></author><author><name sortKey="Dunne, M" uniqKey="Dunne M">M. Dunne</name></author><author><name sortKey="Storm, G" uniqKey="Storm G">G. Storm</name></author><author><name sortKey="Allen, C" uniqKey="Allen C">C. Allen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, X" uniqKey="Du X">X. Du</name></author><author><name sortKey="Khan, A R" uniqKey="Khan A">A.R. Khan</name></author><author><name sortKey="Fu, M" uniqKey="Fu M">M. Fu</name></author><author><name sortKey="Ji, J" uniqKey="Ji J">J. Ji</name></author><author><name sortKey="Yu, A" uniqKey="Yu A">A. Yu</name></author><author><name sortKey="Zhai, G" uniqKey="Zhai G">G. Zhai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khuroo, T" uniqKey="Khuroo T">T. Khuroo</name></author><author><name sortKey="Verma, D" uniqKey="Verma D">D. Verma</name></author><author><name sortKey="Khuroo, A" uniqKey="Khuroo A">A. Khuroo</name></author><author><name sortKey="Ali, A" uniqKey="Ali A">A. Ali</name></author><author><name sortKey="Iqbal, Z" uniqKey="Iqbal Z">Z. Iqbal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gupta, D" uniqKey="Gupta D">D. Gupta</name></author><author><name sortKey="Kumar, M" uniqKey="Kumar M">M. Kumar</name></author><author><name sortKey="Tyagi, P" uniqKey="Tyagi P">P. Tyagi</name></author><author><name sortKey="Kapoor, S" uniqKey="Kapoor S">S. Kapoor</name></author><author><name sortKey="Tyagi, A" uniqKey="Tyagi A">A. Tyagi</name></author><author><name sortKey="Barman, T K" uniqKey="Barman T">T.K. Barman</name></author><author><name sortKey="Kharbanda, S" uniqKey="Kharbanda S">S. Kharbanda</name></author><author><name sortKey="Kufe, D" uniqKey="Kufe D">D. Kufe</name></author><author><name sortKey="Singh, H" uniqKey="Singh H">H. Singh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chowdhury, P" uniqKey="Chowdhury P">P. Chowdhury</name></author><author><name sortKey="Nagesh, P K B" uniqKey="Nagesh P">P.K.B. Nagesh</name></author><author><name sortKey="Hatami, E" uniqKey="Hatami E">E. Hatami</name></author><author><name sortKey="Wagh, S" uniqKey="Wagh S">S. Wagh</name></author><author><name sortKey="Dan, N" uniqKey="Dan N">N. Dan</name></author><author><name sortKey="Tripathi, M K" uniqKey="Tripathi M">M.K. Tripathi</name></author><author><name sortKey="Khan, S" uniqKey="Khan S">S. Khan</name></author><author><name sortKey="Hafrez, B B" uniqKey="Hafrez B">B.B. Hafrez</name></author><author><name sortKey="Meibohm, B" uniqKey="Meibohm B">B. Meibohm</name></author><author><name sortKey="Chauhan, S C" uniqKey="Chauhan S">S.C. Chauhan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, R" uniqKey="Huang R">R. Huang</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q. Wang</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name></author><author><name sortKey="Zhu, J" uniqKey="Zhu J">J. Zhu</name></author><author><name sortKey="Sun, B" uniqKey="Sun B">B. Sun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nguyen, H T" uniqKey="Nguyen H">H.T. Nguyen</name></author><author><name sortKey="Tran, T H" uniqKey="Tran T">T.H. Tran</name></author><author><name sortKey="Thapa, R K" uniqKey="Thapa R">R.K. Thapa</name></author><author><name sortKey="Phung, C D" uniqKey="Phung C">C.D. Phung</name></author><author><name sortKey="Shin, B S" uniqKey="Shin B">B.S. Shin</name></author><author><name sortKey="Jeong, J H" uniqKey="Jeong J">J.H. Jeong</name></author><author><name sortKey="Choi, H G" uniqKey="Choi H">H.G. Choi</name></author><author><name sortKey="Yong, C S" uniqKey="Yong C">C.S. Yong</name></author><author><name sortKey="Kim, J O" uniqKey="Kim J">J.O. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, R" uniqKey="Huang R">R. Huang</name></author><author><name sortKey="Sun, Y" uniqKey="Sun Y">Y. Sun</name></author><author><name sortKey="Zhang, X Y" uniqKey="Zhang X">X.Y. Zhang</name></author><author><name sortKey="Sun, B W" uniqKey="Sun B">B.W. Sun</name></author><author><name sortKey="Wang, Q C" uniqKey="Wang Q">Q.C. Wang</name></author><author><name sortKey="Zhu, Z" uniqKey="Zhu Z">Z. Zhu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morimura, O" uniqKey="Morimura O">O. Morimura</name></author><author><name sortKey="Minami, T" uniqKey="Minami T">T. Minami</name></author><author><name sortKey="Kijima, T" uniqKey="Kijima T">T. Kijima</name></author><author><name sortKey="Koyama, S" uniqKey="Koyama S">S. Koyama</name></author><author><name sortKey="Otsuka, T" uniqKey="Otsuka T">T. Otsuka</name></author><author><name sortKey="Kinehara, Y" uniqKey="Kinehara Y">Y. Kinehara</name></author><author><name sortKey="Osa, A" uniqKey="Osa A">A. Osa</name></author><author><name sortKey="Higashiguchi, M" uniqKey="Higashiguchi M">M. Higashiguchi</name></author><author><name sortKey="Miyake, K" uniqKey="Miyake K">K. Miyake</name></author><author><name sortKey="Nagatomo, I" uniqKey="Nagatomo I">I. Nagatomo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Daniels, B" uniqKey="Daniels B">B. Daniels</name></author><author><name sortKey="Kiely, B E" uniqKey="Kiely B">B.E. Kiely</name></author><author><name sortKey="Lord, S J" uniqKey="Lord S">S.J. Lord</name></author><author><name sortKey="Houssami, N" uniqKey="Houssami N">N. Houssami</name></author><author><name sortKey="Lu, C Y" uniqKey="Lu C">C.Y. Lu</name></author><author><name sortKey="Ward, R L" uniqKey="Ward R">R.L. Ward</name></author><author><name sortKey="Pearson, S A" uniqKey="Pearson S">S.A. Pearson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baselga, J" uniqKey="Baselga J">J. Baselga</name></author><author><name sortKey="Manikhas, A" uniqKey="Manikhas A">A. Manikhas</name></author><author><name sortKey="Cortes, J" uniqKey="Cortes J">J. Cortés</name></author><author><name sortKey="Llombart, A" uniqKey="Llombart A">A. Llombart</name></author><author><name sortKey="Roman, L" uniqKey="Roman L">L. Roman</name></author><author><name sortKey="Semiglazov, V F" uniqKey="Semiglazov V">V.F. Semiglazov</name></author><author><name sortKey="Byakhov, M" uniqKey="Byakhov M">M. Byakhov</name></author><author><name sortKey="Lokanatha, D" uniqKey="Lokanatha D">D. Lokanatha</name></author><author><name sortKey="Forenza, S" uniqKey="Forenza S">S. Forenza</name></author><author><name sortKey="Goldfarb, R H" uniqKey="Goldfarb R">R.H. Goldfarb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roman, J V" uniqKey="Roman J">J.V. Román</name></author><author><name sortKey="Rodriguez Rodriguez, J A" uniqKey="Rodriguez Rodriguez J">J.A. Rodríguez-Rodríguez</name></author><author><name sortKey="Martin Del Valle, E M" uniqKey="Martin Del Valle E">E.M. Martín del Valle</name></author><author><name sortKey="Galan, M A" uniqKey="Galan M">M.A. Galán</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, J" uniqKey="Huang J">J. Huang</name></author><author><name sortKey="Li, J" uniqKey="Li J">J. Li</name></author><author><name sortKey="Feng, Y" uniqKey="Feng Y">Y. Feng</name></author><author><name sortKey="Li, K" uniqKey="Li K">K. Li</name></author><author><name sortKey="Yan, H" uniqKey="Yan H">H. Yan</name></author><author><name sortKey="Gao, P" uniqKey="Gao P">P. Gao</name></author><author><name sortKey="Xiao, T" uniqKey="Xiao T">T. Xiao</name></author><author><name sortKey="Wang, C" uniqKey="Wang C">C. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shah, A" uniqKey="Shah A">A. Shah</name></author><author><name sortKey="Shah, A M" uniqKey="Shah A">A.M. Shah</name></author><author><name sortKey="Parveen, N" uniqKey="Parveen N">N. Parveen</name></author><author><name sortKey="Rehman, Z" uniqKey="Rehman Z">Z. Rehman</name></author><author><name sortKey="Khan, S Z" uniqKey="Khan S">S.Z. Khan</name></author><author><name sortKey="Rana, U A" uniqKey="Rana U">U.A. Rana</name></author><author><name sortKey="Khan, S U" uniqKey="Khan S">S.U. Khan</name></author><author><name sortKey="Nisar, J" uniqKey="Nisar J">J. Nisar</name></author><author><name sortKey="Lashin, A" uniqKey="Lashin A">A. Lashin</name></author><author><name sortKey="Qureshi, R" uniqKey="Qureshi R">R. Qureshi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fytas, C" uniqKey="Fytas C">C. Fytas</name></author><author><name sortKey="Zoidis, G" uniqKey="Zoidis G">G. Zoidis</name></author><author><name sortKey="Tsotinis, A" uniqKey="Tsotinis A">A. Tsotinis</name></author><author><name sortKey="Fytas, G" uniqKey="Fytas G">G. Fytas</name></author><author><name sortKey="Khan, M A" uniqKey="Khan M">M.A. Khan</name></author><author><name sortKey="Khtar, S A" uniqKey="Khtar S">S.A. Khtar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin Del Valle, E M" uniqKey="Martin Del Valle E">E.M. Martín del Valle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shelley, H" uniqKey="Shelley H">H. Shelley</name></author><author><name sortKey="Babu, R J" uniqKey="Babu R">R.J. Babu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oroujeni, M" uniqKey="Oroujeni M">M. Oroujeni</name></author><author><name sortKey="Kaboudin, B" uniqKey="Kaboudin B">B. Kaboudin</name></author><author><name sortKey="Xia, W" uniqKey="Xia W">W. Xia</name></author><author><name sortKey="Johsson, P" uniqKey="Johsson P">P. Jöhsson</name></author><author><name sortKey="Ossipov, D A" uniqKey="Ossipov D">D.A. Ossipov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Basha, R Y" uniqKey="Basha R">R.Y. Basha</name></author><author><name sortKey="Kumar, S" uniqKey="Kumar S">S. Kumar</name></author><author><name sortKey="Doble, M" uniqKey="Doble M">M. Doble</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shah, M" uniqKey="Shah M">M. Shah</name></author><author><name sortKey="Shah, V" uniqKey="Shah V">V. Shah</name></author><author><name sortKey="Ghosh, A" uniqKey="Ghosh A">A. Ghosh</name></author><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z. Zhang</name></author><author><name sortKey="Minko, T" uniqKey="Minko T">T. Minko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bhatt, P" uniqKey="Bhatt P">P. Bhatt</name></author><author><name sortKey="Lalani, R" uniqKey="Lalani R">R. Lalani</name></author><author><name sortKey="Vhora, I" uniqKey="Vhora I">I. Vhora</name></author><author><name sortKey="Patil, S" uniqKey="Patil S">S. Patil</name></author><author><name sortKey="Amrutiya, J" uniqKey="Amrutiya J">J. Amrutiya</name></author><author><name sortKey="Misra, A" uniqKey="Misra A">A. Misra</name></author><author><name sortKey="Mashru, R" uniqKey="Mashru R">R. Mashru</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alcaro, S" uniqKey="Alcaro S">S. Alcaro</name></author><author><name sortKey="Ventura, C A" uniqKey="Ventura C">C.A. Ventura</name></author><author><name sortKey="Paolino, D" uniqKey="Paolino D">D. Paolino</name></author><author><name sortKey="Battaglia, D" uniqKey="Battaglia D">D. Battaglia</name></author><author><name sortKey="Ortuso, F" uniqKey="Ortuso F">F. Ortuso</name></author><author><name sortKey="Cattel, L" uniqKey="Cattel L">L. Cattel</name></author><author><name sortKey="Puglisi, G" uniqKey="Puglisi G">G. Puglisi</name></author><author><name sortKey="Fresta, M" uniqKey="Fresta M">M. Fresta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamada, H" uniqKey="Hamada H">H. Hamada</name></author><author><name sortKey="Ishihara, K" uniqKey="Ishihara K">K. Ishihara</name></author><author><name sortKey="Masuoka, N" uniqKey="Masuoka N">N. Masuoka</name></author><author><name sortKey="Mikuni, K" uniqKey="Mikuni K">K. Mikuni</name></author><author><name sortKey="Nakajima, N" uniqKey="Nakajima N">N. Nakajima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Badea, I" uniqKey="Badea I">I. Badea</name></author><author><name sortKey="Ciutaru, D" uniqKey="Ciutaru D">D. Ciutaru</name></author><author><name sortKey="Lazar, L" uniqKey="Lazar L">L. Lazar</name></author><author><name sortKey="Nicolescu, D" uniqKey="Nicolescu D">D. Nicolescu</name></author><author><name sortKey="Tudose, A" uniqKey="Tudose A">A. Tudose</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chung, W J" uniqKey="Chung W">W.J. Chung</name></author><author><name sortKey="Lee, D Y" uniqKey="Lee D">D.Y. Lee</name></author><author><name sortKey="Yoo, S Y" uniqKey="Yoo S">S.Y. Yoo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Campuzano, S" uniqKey="Campuzano S">S. Campuzano</name></author><author><name sortKey="Yanez Sede O, P" uniqKey="Yanez Sede O P">P. Yánez-Sedeño</name></author><author><name sortKey="Pingarr N, J M" uniqKey="Pingarr N J">J.M. Pingarrón</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kelestemur, S" uniqKey="Kelestemur S">S. Kelestemur</name></author><author><name sortKey="Altunbek, M" uniqKey="Altunbek M">M. Altunbek</name></author><author><name sortKey="Culha, M" uniqKey="Culha M">M. Culha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hua, J" uniqKey="Hua J">J. Hua</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z. Li</name></author><author><name sortKey="Xia, W" uniqKey="Xia W">W. Xia</name></author><author><name sortKey="Yang, N" uniqKey="Yang N">N. Yang</name></author><author><name sortKey="Gong, J" uniqKey="Gong J">J. Gong</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name></author><author><name sortKey="Qiao, C" uniqKey="Qiao C">C. Qiao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bradford, M M" uniqKey="Bradford M">M.M. Bradford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Montero, J C" uniqKey="Montero J">J.C. Montero</name></author><author><name sortKey="Seoane, S" uniqKey="Seoane S">S. Seoane</name></author><author><name sortKey="Oca A, A" uniqKey="Oca A A">A. Ocaña</name></author><author><name sortKey="Pandiella, A" uniqKey="Pandiella A">A. Pandiella</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Esparis Ogando, A" uniqKey="Esparis Ogando A">A. Esparís-Ogando</name></author><author><name sortKey="Diaz Rodriguez, E" uniqKey="Diaz Rodriguez E">E. Díaz-Rodríguez</name></author><author><name sortKey="Montero, J C" uniqKey="Montero J">J.C. Montero</name></author><author><name sortKey="Yuste, L" uniqKey="Yuste L">L. Yuste</name></author><author><name sortKey="Crespo, P" uniqKey="Crespo P">P. Crespo</name></author><author><name sortKey="Pandiella, A" uniqKey="Pandiella A">A. Pandiella</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mosmann, T" uniqKey="Mosmann T">T. Mosmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haug, A" uniqKey="Haug A">A. Haug</name></author><author><name sortKey="Larsen, B" uniqKey="Larsen B">B. Larsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khalili, F" uniqKey="Khalili F">F. Khalili</name></author><author><name sortKey="Henri, A" uniqKey="Henri A">A. Henri</name></author><author><name sortKey="East, A L L" uniqKey="East A">A.L.L. East</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaufman, P A" uniqKey="Kaufman P">P.A. Kaufman</name></author><author><name sortKey="Wildiers, H" uniqKey="Wildiers H">H. Wildiers</name></author><author><name sortKey="Freyer, G" uniqKey="Freyer G">G. Freyer</name></author><author><name sortKey="Kemeny, M" uniqKey="Kemeny M">M. Kemeny</name></author><author><name sortKey="Goncalves, A" uniqKey="Goncalves A">A. Gonçalves</name></author><author><name sortKey="Jerusalem, G" uniqKey="Jerusalem G">G. Jerusalem</name></author><author><name sortKey="Stopeck, A" uniqKey="Stopeck A">A. Stopeck</name></author><author><name sortKey="Vrindavanam, N" uniqKey="Vrindavanam N">N. Vrindavanam</name></author><author><name sortKey="Dalenc, F" uniqKey="Dalenc F">F. Dalenc</name></author><author><name sortKey="Nanayakkara, N" uniqKey="Nanayakkara N">N. Nanayakkara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Ramshorst, M S" uniqKey="Van Ramshorst M">M.S. Van Ramshorst</name></author><author><name sortKey="Van Werkhoven, E" uniqKey="Van Werkhoven E">E. van Werkhoven</name></author><author><name sortKey="Mandjes, I A M" uniqKey="Mandjes I">I.A.M. Mandjes</name></author><author><name sortKey="Schot, M" uniqKey="Schot M">M. Schot</name></author><author><name sortKey="Wesseling, J" uniqKey="Wesseling J">J. Wesseling</name></author><author><name sortKey="Vrancken Peeters, M T F D" uniqKey="Vrancken Peeters M">M.T.F.D. Vrancken Peeters</name></author><author><name sortKey="Meerum Terwogt, J M" uniqKey="Meerum Terwogt J">J.M. Meerum Terwogt</name></author><author><name sortKey="Bos, M E M" uniqKey="Bos M">M.E.M. Bos</name></author><author><name sortKey="Oosterkamp, H M" uniqKey="Oosterkamp H">H.M. Oosterkamp</name></author><author><name sortKey="Rodenhuis, S" uniqKey="Rodenhuis S">S. Rodenhuis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Subik, K" uniqKey="Subik K">K. Subik</name></author><author><name sortKey="Lee, J F" uniqKey="Lee J">J.F. Lee</name></author><author><name sortKey="Baxter, L" uniqKey="Baxter L">L. Baxter</name></author><author><name sortKey="Strzepek, T" uniqKey="Strzepek T">T. Strzepek</name></author><author><name sortKey="Costello, D" uniqKey="Costello D">D. Costello</name></author><author><name sortKey="Crowley, P" uniqKey="Crowley P">P. Crowley</name></author><author><name sortKey="Xing, L" uniqKey="Xing L">L. Xing</name></author><author><name sortKey="Hung, M C" uniqKey="Hung M">M.C. Hung</name></author><author><name sortKey="Bonfiglio, T" uniqKey="Bonfiglio T">T. Bonfiglio</name></author><author><name sortKey="Hicks, D G" uniqKey="Hicks D">D.G. Hicks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, J" uniqKey="He J">J. He</name></author><author><name sortKey="Jing, Y" uniqKey="Jing Y">Y. Jing</name></author><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name></author><author><name sortKey="Qian, X" uniqKey="Qian X">X. Qian</name></author><author><name sortKey="Xu, Q" uniqKey="Xu Q">Q. Xu</name></author><author><name sortKey="Li, F S" uniqKey="Li F">F.S. Li</name></author><author><name sortKey="Liu, L Z" uniqKey="Liu L">L.Z. Liu</name></author><author><name sortKey="Jiang, B H" uniqKey="Jiang B">B.H. Jiang</name></author><author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y. Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patel, R V" uniqKey="Patel R">R.V. Patel</name></author><author><name sortKey="Park, S W" uniqKey="Park S">S.W. Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Donahue, N D" uniqKey="Donahue N">N.D. Donahue</name></author><author><name sortKey="Acar, H" uniqKey="Acar H">H. Acar</name></author><author><name sortKey="Wilhelm, S" uniqKey="Wilhelm S">S. Wilhelm</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mohanraj, V J" uniqKey="Mohanraj V">V.J. Mohanraj</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alessandrini, F" uniqKey="Alessandrini F">F. Alessandrini</name></author><author><name sortKey="Pezze, L" uniqKey="Pezze L">L. Pezzè</name></author><author><name sortKey="Ciribilli, Y" uniqKey="Ciribilli Y">Y. Ciribilli</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Espagne</li></country><region><li>Castille-et-León</li></region></list><tree><country name="Espagne"><region name="Castille-et-León"><name sortKey="Nieto, Celia" sort="Nieto, Celia" uniqKey="Nieto C" first="Celia" last="Nieto">Celia Nieto</name></region><name sortKey="Centa, Ariana" sort="Centa, Ariana" uniqKey="Centa A" first="Ariana" last="Centa">Ariana Centa</name><name sortKey="Martin Del Valle, Eva M" sort="Martin Del Valle, Eva M" uniqKey="Martin Del Valle E" first="Eva M." last="Martín Del Valle">Eva M. Martín Del Valle</name><name sortKey="Pandiella, Atanasio" sort="Pandiella, Atanasio" uniqKey="Pandiella A" first="Atanasio" last="Pandiella">Atanasio Pandiella</name><name sortKey="Rodriguez Rodriguez, Jesus A" sort="Rodriguez Rodriguez, Jesus A" uniqKey="Rodriguez Rodriguez J" first="Jesús A." last="Rodríguez-Rodríguez">Jesús A. Rodríguez-Rodríguez</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000553 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000553 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:6669497
|texte= Paclitaxel-Trastuzumab Mixed Nanovehicle to Target HER2-Overexpressing Tumors
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31261957" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |